Biocorona: The Shadowed Side of Nanoparticles | Juniper Publishers

Biocorona: The Shadowed Side of Nanoparticles by Fabiola Porta in Modern Applications of Bioequivalence & Bioavailability | Juniper Publishers

Under physiological conditions nanomaterials encounter a vast number of proteins in circulation. Those two dynamically interact with each other forming the so called biocorona. Accordingly, the biocorona is the layer of proteins in direct contact with the surface of nanomaterials, which may influence physical parameters of colloidal suspensions and thereby impact pharmacokinetics and dynamics of the formulated compound. Even though many experimental data have been gathered to understand the formation and the composition of the biocorona, the physiological impact of this protein layer is still a pristine area of research. The nature of the nanomaterials and the surface modifications performed to achieve controlled release of bioactive compounds influence thoroughly the nature of the biocorona. The focus of this review will be to evaluate how the protein-particles interactions influence the therapeutic outcome of nano formulated drugs.

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